Tnfsf11 CLIA Kit for Mouse(Mus musculus) | EIAab.comTnfsf11 CLIA Kit for Mouse(Mus musculus)

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Tnfsf11 (Gene name),

Tumor necrosis factor ligand superfamily member 11 (Protein name ), TNF11_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Tnfsf11(Opgl;Rankl;Trance);

Protein name:

Tumor necrosis factor ligand superfamily member 11;

Alternative:

Osteoprotegerin ligand(OPGL);Osteoclast differentiation factor(ODF);TNF-related activation-induced cytokine(TRANCE);Receptor activator of nuclear factor kappa-B ligand(RANKL);

CD:

CD254;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotrimer.

Function:

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subcellular Location:

Tumor necrosis factor ligand superfamily member 11, soluble form Secreted

Protein Attributes:

Sequence length:

316

Sequence:

50:

100:

150:

200:

250:

300:

316:

DQDATYFGAF | KVQDID

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00229

SMR:

O35235

String:

O35235

KEGG:

mmu:21943

UniGene:

Mm.249221

Uniprot:

O35235

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ELISA Kit for Mouse Tumor necrosis factor ligand superfamily member 11

Cat.:

E0855r

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96T

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ELISA Kit for Mouse Tumor necrosis factor ligand superfamily member 11

Cat.:

E0855m

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96T

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ELISA Kit for Mouse Tumor necrosis factor ligand superfamily member 11

Cat.:

E0855h

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CLIA Kit for Mouse Tumor necrosis factor ligand superfamily member 11

Cat.:

U0855h

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96T

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CLIA Kit for Mouse Tumor necrosis factor ligand superfamily member 11

Cat.:

U0855m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Tumor necrosis factor ligand superfamily member 11

Cat.:

U0855r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 11

Cat.:

P0855Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 11

Cat.:

P0855Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 11

Cat.:

P0855Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 11

Protein for Mouse Tumor necrosis factor ligand superfamily member 11

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells."
Wong B.R. , Rho J. , Arron J. , Robinson E. , Orlinick J. , Chao M. , Kalachikov S. , Cayani E. , Bartlett F.S. III , Frankel W.N. , Lee S.Y. , Choi Y.
J. Biol. Chem.272:25190-25194(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Hybridoma.
2.

"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function."
Anderson D.M. , Maraskovsky E. , Billingsley W.L. , Dougall W.C. , Tometsko M.E. , Roux E.R. , Teepe M.C. , DuBose R.F. , Cosman D. , Galibert L.
Nature390:175-179(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Thymic lymphoma.
3.

"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation."
Lacey D.L. , Timms E. , Tan H.-L. , Kelley M.J. , Dunstan C.R. , Burgess T. , Elliott R. , Colombero A. , Elliott G. , Scully S. , Hsu H. , Sullivan J. , Hawkins N. , Davy E. , Capparelli C. , Eli A. , Qian Y.-X. , Kaufman S. , more...
Cell93:165-176(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Bone marrow.
4.

"Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL."
Yasuda H. , Shima N. , Nakagawa N. , Yamaguchi K. , Kinosaki M. , Mochizuki S. , Tomoyasu A. , Yano K. , Goto M. , Murakami A. , Tsuda E. , Morinaga T. , Higashio K. , Udagawa N. , Takahashi N. , Suda T.
Proc. Natl. Acad. Sci. U.S.A.95:3597-3602(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Bone marrow stroma.
5.

"Cloning and characterization of the gene encoding mouse osteoclast differentiation factor."
Kodaira K. , Kodaira K. , Mizuno A. , Yasuda H. , Shima N. , Murakami A. , Ueda M. , Higashio K.
Gene230:121-127(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
strain: 129.
6.

"Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus."
Ikeda T. , Kasai M. , Utsuyama M. , Hirokawa K.
Endocrinology142:1419-1426(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
7.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6J.
8.

"Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival."
Lum L. , Wong B.R. , Josien R. , Becherer J.D. , Erdjument-Bromage H. , Schloendorff J. , Tempst P. , Choi Y. , Blobel C.P.
J. Biol. Chem.274:13613-13618(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 139-147;PROTEOLYTIC PROCESSING;GLYCOSYLATION
9.

"Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity."
Lam J. , Nelson C.A. , Ross F.P. , Teitelbaum S.L. , Fremont D.H.
J. Clin. Invest.108:971-979(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 158-316;SUBUNIT
10.

"Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution."
Ito S. , Wakabayashi K. , Ubukata O. , Hayashi S. , Okada F. , Hata T.
J. Biol. Chem.277:6631-6636(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 137-316;SUBUNIT
11.

"Structural and functional insights of RANKL-RANK interaction and signaling."
Liu C. , Walter T.S. , Huang P. , Zhang S. , Zhu X. , Wu Y. , Wedderburn L.R. , Tang P. , Owens R.J. , Stuart D.I. , Ren J. , Gao B.
J. Immunol.184:6910-6919(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 158-316 IN COMPLEX WITH TNFRSF11A;INTERACTION WITH TNFRSF11A;SUBUNIT
12.

"RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor."
Nelson C.A. , Warren J.T. , Wang M.W. , Teitelbaum S.L. , Fremont D.H.
Structure20:1971-1982(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 162-316 IN COMPLEX WITH TNFRSF11B

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